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In‐situ Glycine Sensor Development Based ZnO/Al 2 O 3 /Cr 2 O 3 Nanoparticles
Author(s) -
Alam M. M.,
Asiri Abdullah M.,
Uddin M. T.,
Islam M. A.,
Rahman Mohammed M.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802750
Subject(s) - calibration curve , ternary operation , detection limit , materials science , analytical chemistry (journal) , nanoparticle , reproducibility , calibration , linear range , glycine , nanotechnology , chemistry , chromatography , mathematics , computer science , statistics , programming language , biochemistry , amino acid
Initially, low‐dimensional ternary nanoparticles of ZnO/Al 2 O 3 /Cr 2 O 3 were synthesized using reliable solvothermal process and successfully implemented to fabricate enzyme‐less selective glycine (Gly) sensor. The calibration curve was plotted from the linear relation of current versus concentration of glycine. By using the slope of resultant calibration curve, the sensitivity (2.09*10 2 μAμM −1 cm −2 ) of Gly sensor was estimated by considering the active surface area of fabricated sensor probe. The proposed enzyme‐free Gly biosensor was found linear over large concentration range of 0.1 nM ∼ 1.0 μM, known as linear dynamic range (LDR). The detection limit (82.25±4.11 pM) was calculated at signal to noise ratio of 3 from the calibration curve. The proposed enzyme‐less Gly sensor was exhibited good reproducibility, long‐term stability and efficiency to detect Gly in real biological samples by electrochemical approach. Thus, this novel research methodology might be a good technique for the development of enzyme‐less sensor using ternary metal oxide nanoparticles onto GCE for the biomedical applications.