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NaN 3 /NH 4 Cl‐Promoted Aza‐Cyclization: A Convenient Route for Bio‐Active Diverse Isoindolinone Derivatives
Author(s) -
Ali Sk Asraf,
Bhaumik Sanjay,
Jana Akash,
Manna Susanta Kumar,
Ikbal Mohammed,
Mandal Arabinda,
Bera Anirban,
Jana Avijit,
Samanta Shubhankar
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802696
Subject(s) - reagent , combinatorial chemistry , chemistry , tricyclic , substrate (aquarium) , derivative (finance) , bicyclic molecule , fluorophore , transformation (genetics) , cascade , stereochemistry , organic chemistry , physics , fluorescence , biology , chromatography , biochemistry , gene , ecology , quantum mechanics , financial economics , economics
An efficient substrate dependent NaN 3 /NH 4 Cl promoted aza‐cyclization was developed via metal free cascade transformation. A wide variety of bicyclic/tricyclic isoindolinone derivative was achieved with excellent diastereoselectivity from achiral reagent system. This protocol also provided synthetic route of dopamine D 4 receptor in short way. The bio‐imaging study towards CHO cell line with our isoindolinone embedded new fluorophore was also demonstrated.