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Facile Reagent‐Free Synthesis of Furo[3,2‐ c ]pyridinones and Their Polynuclear Analogues with DDQ as Precursor
Author(s) -
Li JiangSheng,
Yang Qian,
Chen GuoQin,
Li ZhiWei,
Huang PengMian
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802686
Subject(s) - reagent , furan , pyrimidinones , chemistry , combinatorial chemistry , block (permutation group theory) , organic chemistry , mathematics , geometry
A variety of furo[3,2‐ c ]pyridinones and their polynuclear analogues were achieved via a one‐step oxidative cyclization using 2,3‐dichloro‐5,6‐dicyanobenzoquinone (DDQ) as both the oxidant and the building block without auxiliary reagents under very mild conditions. The 4‐hydroxylpyridinones, pyranones, and pyrimidinones are applicable in such transformations, demonstrating the astonishing generality of this furan assembly. This powerful protocol enables ready access to furan‐fused heterocycles.