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Methyl Red as Organocatalyst for Arylation of Unactivated Benzene Derivatives with Aryl Halides
Author(s) -
Ghonchepour Ehsan,
Islami Mohammad Reza,
Tikdari Ahmad Momeni
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802643
Subject(s) - chemistry , aryl , halide , catalysis , reagent , biphenyl , benzene , transition metal , stoichiometry , combinatorial chemistry , organic chemistry , alkyl
Transition‐metal‐free arylation of benzene derivatives with aryl halides using KO t Bu and methyl red as an organocatalyst is described in this letter. This facile one‐pot reaction is reported as an unprecedented C−H functionalization protocol for the synthesis of biaryls. Several organic acids we tested and among them, methyl red was found to be the best catalyst for this cross‐coupling. This method was designed based on the principles of green chemistry due to avoiding the use of stoichiometric of reagents, any expensive and toxic transition‐metal catalysts. We believe this procedure will become an acceptable method and could be very well compared with known protocols for biphenyl cross coupling.