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An Efficient Protocol for the Synthesis of 1, 5‐ disubstituted Tetrazole Derivatives via a TMS‐N 3 Based Ugi Reaction and their Anti‐cancer Activity
Author(s) -
Gohel Jyoti N.,
Lunagariya Kaushikkumar S.,
Kapadiya Khushal M.,
Khunt Ranjan C.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802638
Subject(s) - pharmacophore , isocyanide , tetrazole , ugi reaction , combinatorial chemistry , chemistry , aldehyde , aryl , cancer cell lines , condensation reaction , molecule , stereochemistry , catalysis , organic chemistry , cancer cell , cancer , medicine , alkyl
In current research scenario, an efficient synthesis has been developed for novel tetrazole scaffolds by single step multicomponent reaction. One of the most promising pathways is Ugi multi‐component process for the coupling of four different components in a single reaction step and isolate lead molecule which may serve better life to the society. The syntheses of tetrazoles were undertaken by the Ugi‐Multi Component approach with the condensation of aromatic aldehyde containing active pharmacophore, various aryl amines, isocyanide (cyclohexyl isocyanide) and TMS‐N 3 under catalyst free reaction condition at room temperature. The structural conformation were carried out by most acceptable spectroscopic technique i.e . MS, IR, NMR and single crystal study (XRD) and potency of compounds (4a to 4h) were checked at NIH (National Institute of Health) use 60 different cell‐lines with respect to nine cancer panels among which compounds 4a and 4b have been found to be more potent against different cell lines.