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Cisplatin‐Loaded Polymeric Micelles with Aggregation‐Induced Emission Feature for Cellular Imaging and Chemotherapy
Author(s) -
Li Li-Ping
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802542
Subject(s) - biocompatibility , micelle , drug delivery , cisplatin , nanoparticle , nanotechnology , cytotoxicity , peg ratio , drug , aggregation induced emission , chemistry , cancer cell , materials science , biophysics , in vitro , fluorescence , cancer , chemotherapy , pharmacology , organic chemistry , biochemistry , medicine , biology , quantum mechanics , physics , surgery , finance , aqueous solution , economics
Imaging‐guided disease theranostic nanoplatforms based on polymeric micelles have drawn a broad attention because of their clear visualization, reduced systemic toxicity, enhanced utilization of drugs, and suppressed chemoresistance of tumors, which makes them possess potential application for cancer therapy. Herein, we synthesized a polymeric nanoparticles (Poly(MAD‐alt‐OCE)‐PTZ‐PEG) with novel aggregation‐induced emission (AIE) characteristic based on cheap commercial polymer by the simple and environmental method. These Poly(MAD‐alt‐OCE)‐PTZ‐PEG nanoparticles (NPs) show excellent biocompatibility and fluorescence property, which makes them huge application potential for cellular imaging. Furthermore, the antitumor drug cisplatin Pt(IV) can be loaded efficiently onto the surface of Poly(MAD‐alt‐OCE)‐PTZ‐PEG NPs due to the existence of abundant carboxyl groups on the NPs surface. The well‐controlled Pt(IV)‐loaded yield and great acid‐responsive drug release of these polymeriec micelles enhance cytotoxicity against cancer cells in vitro. Given the cheap raw materials, eco‐friendly method, excellent AIE property, efficient antitumor drug delivery and pH‐controlled drug release, these polymeric NPs would be a potential candidate for cancer diagnosis and therapy in the future.