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Anti‐Proliferative 1,4‐Dihydropyridine and Pyridine Derivatives Synthesized through a Catalyst‐Free, One‐Pot Multi‐Component Reaction
Author(s) -
Sharma Mayank G.,
Vala Ruturajsinh M.,
Patel Divyang M.,
Lagunes Irene,
Fernandes Miguel X.,
Padrón José M.,
Ramkumar Venkatachalam,
Gardas Ramesh L.,
Patel Hitendra M.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802537
Subject(s) - catalysis , pyridine , dihydropyridine , chemistry , yield (engineering) , combinatorial chemistry , cell culture , organic chemistry , materials science , calcium , biology , metallurgy , genetics
In this study, we explored the catalyst‐free one‐pot multi‐component synthesis of 1,4‐dihydropyridine derivatives by following green chemistry protocol. The present approach shows the significant outcomes such as yield up to 94%, catalyst‐free reaction, easy workup procedure and shorter period of reaction time. In this work we also highlighted the comparison of the yields obtained under both neat and solvent media as well. The anti‐proliferative activity of all newly synthesized compounds has been assessed against six human solid tumor cell lines. Seven compounds show good activity against single cell line whereas, compounds having a pyridine scaffold showed significant anti‐proliferative activity.