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Glycerol Micellar Catalysis: An Efficient Multicomponent‐Tandem Green Synthetic Approach to Biologically Important 2, 4‐Disubstituted Thiazole Derivatives
Author(s) -
Tiwari Jyoti,
Singh Swastika,
Tufail Fatima,
Jaiswal Deepali,
Singh Jaya,
Singh Jagdamba
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802511
Subject(s) - thiazole , reagent , chemistry , combinatorial chemistry , yield (engineering) , catalysis , organic chemistry , glycerol , biological activity , green chemistry , reaction conditions , ionic liquid , materials science , metallurgy , biochemistry , in vitro
A convenient, eco‐friendly, one‐pot, multi‐component synthesis of new 2, 4‐disubstituted hydrazinyl ‐ thiazoles under mild reaction conditions has been disclosed. The use of micellar catalysis in glycerol is the key aspect of this methodology which possesses superiority compared to glycerol alone. The other significant aspect of our findings is the use of inexpensive reagents, recyclability, mild reaction conditions, bioorganic compound as solvent cum promoter, short reaction time, high yield, column chromatography free etc. The present work proposes the construction of a variety of biologically active 2, 4‐disubstituted thiazole derivatives using different carbonyl compounds, thiosemicarbazide and α‐bromocarbonyl compounds. Due to its operational simplicity, this green and unexplored protocol can be easily applied for designing novel biologically active compounds.