Premium
HClO 4 ⋅SiO 2 ‐Catalyzed Mechanochemical Protocol: An Effective, Economical and Eco‐friendly Preparation of N ‐( tert ‐butylsulfinyl)imines
Author(s) -
Appa Rama Moorthy,
Lakshmidevi Jangam,
Prasad S. Siva,
Naidu Bandameeda Ramesh,
Narasimhulu Manchala,
Venkateswarlu Katta
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802497
Subject(s) - racemization , catalysis , environmentally friendly , perchloric acid , chemistry , grinding , mortar , molecule , metal , organic chemistry , inorganic chemistry , chemical engineering , combinatorial chemistry , materials science , metallurgy , ecology , composite material , biology , engineering
The imines of Ellman's tert ‐butylsulfinamides have become one of the elementary substrates for the construction of chiral precursors and complex organic molecules. This article reports a mechanochemical access to imines of chiral tert ‐butylsulfinamides with a variety of aldehydes using solid acid catalyst, perchloric acid‐silica (HClO 4 ⋅SiO 2 ) at innocuous reaction environs. The conversion can be carried out at ambient temperature under solvent and metal‐free conditions by (hand) grinding the contents in a mortar at open‐air. The current protocol is highly economical, allows large‐scale preparation, offers a very good to nearly quantitative yields of imines in short reaction times with no product racemization and doesn′t necessitate the moisture‐free conditions.