Pd‐Catalyzed One‐Pot Two‐Step Synthesis of 2‐(1 H ‐indol‐3‐yl)‐2‐phenylindolin‐3‐ones from 2‐Alkynyl Arylazides and Indoles | Zendy

Yong Wanxiong | Zendy; Li Ping | Zendy; Sheng Rong | Zendy; Rao Weidong | Zendy; Zhang Xiaoxiang | Zendy

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Pd‐Catalyzed One‐Pot Two‐Step Synthesis of 2‐(1 H ‐indol‐3‐yl)‐2‐phenylindolin‐3‐ones from 2‐Alkynyl Arylazides and Indoles

Author(s) -

Yong Wanxiong,

Li Ping,

Sheng Rong,

Rao Weidong,

Zhang Xiaoxiang

Publication year - 2018

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201802476

Subject(s) - indoline , indole test , catalysis , chemistry , combinatorial chemistry , medicinal chemistry , reaction conditions , organic chemistry

An efficient palladium‐catalyzed one‐pot two‐step reaction of 2‐alkynyl arylazides and indoles has been developed. The reaction proceeded well under mild reaction conditions and provided the 2‐(1 H ‐indole‐3‐yl)‐2‐phenylindolin‐3‐ones in good to excellent yields.This transformation involves a rearrangement of 1 H ‐indole‐3‐sulfonates generated in situ and Mannich‐type addition of indoline‐3‐ones.

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