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Pd‐Catalyzed One‐Pot Two‐Step Synthesis of 2‐(1 H ‐indol‐3‐yl)‐2‐phenylindolin‐3‐ones from 2‐Alkynyl Arylazides and Indoles
Author(s) -
Yong Wanxiong,
Li Ping,
Sheng Rong,
Rao Weidong,
Zhang Xiaoxiang
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802476
Subject(s) - indoline , indole test , catalysis , chemistry , combinatorial chemistry , medicinal chemistry , reaction conditions , organic chemistry
An efficient palladium‐catalyzed one‐pot two‐step reaction of 2‐alkynyl arylazides and indoles has been developed. The reaction proceeded well under mild reaction conditions and provided the 2‐(1 H ‐indole‐3‐yl)‐2‐phenylindolin‐3‐ones in good to excellent yields.This transformation involves a rearrangement of 1 H ‐indole‐3‐sulfonates generated in situ and Mannich‐type addition of indoline‐3‐ones.