Highly Efficient, Combinatorial and Catalyst‐Free Approach for the Synthesis of 2‐Benzylidenehydrazono‐3‐phenyl‐4‐thiazolidinone‐5‐acetates in Ethanol

We have designed a sustainable, catalyst‐free, combinatorial protocol for the synthesis of highly functionalized thiazolidinone acetate derivatives via multicomponent reaction of aromatic aldehydes, N‐phenylhydrazinecarbothioamide and dimethoxyacetylenedicarboxylate in the ethanol. A consecutive one pot two step environmentally benign procedure has been developed for the synthesis of 2‐Benzylidenehydrazono‐3‐Phenyl‐4‐Thiazolidinone‐5‐Acetate derivatives by adopting regioselective thermal annulation with the operational simplicity with isolation of pure products without using chromatographic purification.