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Synthesis of 2‐(2 H ‐Chromenyl)‐Oxazoles from 2 H ‐Chromene Hemiacetals by Using a Modified Passerini‐Type Reaction
Author(s) -
Huang DengMing,
Li HuiJing,
Wang Quanfu,
Yan Peisheng,
Wu YanChao
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802363
Subject(s) - oxazole , chemistry , furan , combinatorial chemistry , stereochemistry , organic chemistry
A modified Passerini‐type reaction has been developed for the facile synthesis of 2‐(2 H ‐chromenyl)‐oxazoles, in which 2 H ‐chromene hemiacetals instead of the usually used aldehydes were adopted as the key substrates. Derivation of a 2‐(2 H ‐chromenyl)‐oxazole to the respective 2 H ‐chromene peptide and 1‐(2 H ‐chromenyl)‐furan was further accomplished.