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An Eco‐Compatible synthesis of Substituted Hexahydro‐Furo[3,2‐c]pyridine Analogues with the Chitosan/Ionic Liquid Coupled Catalytic System
Author(s) -
Sagir Hozeyfa,
Yadav Vijay B.,
Shamim Shayna,
Kumar Akhilesh,
Yadav Neetu,
Ansari Mohd Danish,
Siddiqui I. R.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802336
Subject(s) - pyridine , reagent , ionic liquid , catalysis , yield (engineering) , chemistry , combinatorial chemistry , pyridinium , aryl , computer science , organic chemistry , materials science , alkyl , metallurgy
An efficient, safe and facile route has been disclosed to synthesise a library of novel aryl‐furo[3,2‐ c ] pyridine derivatives in high yield from the three‐component reaction of N ‐methyl‐4‐piperidinone, aromatic aldehydes and 1‐(2‐oxo‐2‐arylethyl)pyridinium bromides at room temperature. Chitosan/[bmim]OH has been introduced in form of synergistic catalysts that can be recovered and recycled for subsequent reactions. This new protocol avoids hazardous reagents and organic solvents, thus we herein report an eco‐friendly alternative to the existing methods.