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Synthesis of 7 H ‐Indolo[2,3‐ c ]quinolines by Chemoselective Suzuki Reaction Followed by a Ring‐Closing Two‐Fold Buchwald‐Hartwig Reaction of 3‐Bromo‐4‐iodoquinoline
Author(s) -
Rivera Rodisnel Perdomo,
Ehlers Peter,
Rodríguez Eugenio Torres,
Langer Peter
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802320
Subject(s) - chemistry , ring (chemistry) , combinatorial chemistry , medicinal chemistry , reaction conditions , stereochemistry , organic chemistry , catalysis
N ‐functionalized 7 H ‐indolo[2,3‐ c ]quinolines have been synthesized by chemoselective Suzuki‐reaction followed by a ring‐closing two‐fold Buchwald‐Hartwig reaction. The developed methodology allows the application of various anilines, benzyl amines as well as aliphatic amines and led to corresponding products in high yields.