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Synthesis of New Derivatives of 1,2,3‐Triazole‐Linked Phthalazine‐1,4‐dione in Water: Experimental Aspects and Molecular Docking Calculations
Author(s) -
Bakherad Mohammad,
Karami Saeed,
Keivanloo Ali,
Sepehri Saghi
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802096
Subject(s) - phthalazine , chemistry , cycloaddition , bacillus subtilis , combinatorial chemistry , docking (animal) , click chemistry , 1,2,3 triazole , pseudomonas aeruginosa , alkyne , stereochemistry , medicinal chemistry , catalysis , organic chemistry , bacteria , biology , medicine , nursing , genetics
A new series of phthalazine‐based 1,2,3‐triazole derivatives are synthesized by the reaction of 2‐methyl‐3‐(prop‐2‐yn‐1‐yl)‐2,3‐dihydro‐phthalazine‐1,4‐dione or 2,3‐bis(prop‐2‐yn‐1‐yl)‐2,3‐dihydrophthalaz‐ine‐1,4‐dione with aromatic azides via copper‐catalyzed azide‐alkyne cycloaddition reactions in the presence of metformine as a ligand. These reaction procedures have the advantages of high‐to‐excellent yields, short reaction times, mild experimental conditions, and operational simplicity. All the synthesized compounds are screened in vitro for their anti‐bacterial activities against the three bacterial strains Micrococcus luteus , Pseudomonas aeruginosa , and Bacillus subtilis . Furthermore, the results of anti‐bacterial activity of the synthesized compounds was investigated using molecular docking calculations.