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Homochiral Metal Organic Frameworks and Their Usage for the Enantio‐Purification of Racemic Drugs
Author(s) -
Ullah Shakir,
Yunus Uzma,
Bhatti Moazzam H.,
Southon Peter D.,
Iqbal Kiran,
Zaidi Sadia
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802086
Subject(s) - ketoprofen , ibuprofen , enantiomer , flurbiprofen , chemistry , metal organic framework , enantioselective synthesis , adsorption , hexane , racemic mixture , enantiomeric excess , chromatography , organic chemistry , catalysis , pharmacology , medicine
Three new homochiral MOFs (MOF‐808‐S‐ibuprofen, MOF‐808‐S‐proline and MOF‐808‐S‐lactic acid) were synthesized via the post synthetic modification of achiral MOF‐808 and were characterized by various analytical tools. The new homochiral MOFs (HCMOFs) were examined for the enantioselective adsorption of racemic drugs. The n‐hexane solution of racemic ibuprofen, ketoprofen and flurbiprofen were allowed to adsorb in the chiral channels of the HCMOFs. The drugs were desorbed form porous HCMOFs and analysed by chiral HPLC. MOF‐808‐S‐ibuprofen selectively adsorbed R ‐ibuprofen and R ‐ketoprofen with enantiomeric excess ( ee ) of 50 and 56% respectively.