Premium
Peptidomimicry with C 2 ‐Symmetric Oligourea Derivatives of 1,2‐Diaminocyclohexane and 1,2‐Diphenyl‐1,2‐diaminoethane: Chirality and Chain Length‐Dependent Conformation
Author(s) -
Yue Pengyun,
Peng Siqing,
Parkin Sean,
Li Tonglei,
Yu Faquan,
Long Sihui
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801900
Subject(s) - chirality (physics) , chemistry , crystallography , chain (unit) , stereochemistry , diffraction , physics , chiral symmetry , quantum mechanics , nambu–jona lasinio model , quark
To study whether C 2 symmetric oligoureas form secondary structures such as sheets and helices/turns to serve as peptidomimetics, conformations of oligoureas composed of 1,2‐diaminocyclohexane and 1,2‐diphenyl‐1,2‐diaminoethane were investigated using X‐ray diffraction, UV, CD and NMR spectroscopic methods. Alternating heterochiral diamines in these chains strongly favored helical conformations. The conformations of C 2 ‐symmetric chains of homochiral diamines were more conditional, giving indications of conditional extended and helical structure.