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Synthesis of Polysubstituted Pyridines and Indoles by a Palladium‐Catalyzed Catellani‐type Alkylation‐Alkenylation Sequence
Author(s) -
Fu Jingjing,
Gao Yadong,
Qi Xiangbing,
Jiang Chao
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801890
Subject(s) - alkylation , palladium , catalysis , pyridine , surface modification , norbornene , chemistry , combinatorial chemistry , indole test , molecule , metal , organic chemistry , polymer , copolymer
The C−H functionalization of heterocycles has attracted extensive attention recently due to the ubiquity of substituted heterocycles in natural products, drugs, and other bioactive molecules. The Catellani‐type C−H functionalization, which is a palladium‐catalyzed and norbornene‐mediated coupling process, can properly overcome the metal poisoning between hetero atoms and metal catalyst. Based on this fact, we developed a method to efficiently build multiple C−C bonds on the pyridine and indole substrates by one‐pot process and finally achieved ortho ‐alkylation/ ipso ‐alkenylation in moderate to good yields.