Synthesis of Polysubstituted Pyridines and Indoles by a Palladium‐Catalyzed Catellani‐type Alkylation‐Alkenylation Sequence

The C−H functionalization of heterocycles has attracted extensive attention recently due to the ubiquity of substituted heterocycles in natural products, drugs, and other bioactive molecules. The Catellani‐type C−H functionalization, which is a palladium‐catalyzed and norbornene‐mediated coupling process, can properly overcome the metal poisoning between hetero atoms and metal catalyst. Based on this fact, we developed a method to efficiently build multiple C−C bonds on the pyridine and indole substrates by one‐pot process and finally achieved ortho ‐alkylation/ ipso ‐alkenylation in moderate to good yields.