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Birnessite: A New‐Generation and Cost Effective Ion Exchange Material for Separation of Clinical‐Grade 90 Y from 90 Sr/ 90 Y Mixture
Author(s) -
Chakravarty Rubel,
Bevara Samatha,
Bahadur Jitendra,
Chakraborty Sudipta,
Dev Sarma Haladhar,
Achary S. Nagabhusan,
Dash Ashutosh,
Tyagi Avesh Kumar
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801822
Subject(s) - birnessite , chemistry , ion exchange , nuclear chemistry , yield (engineering) , sodium , radiochemistry , ion , materials science , catalysis , organic chemistry , manganese oxide , metallurgy
The widespread clinical utilization of 90 Y for preparation of target specific radiopharmaceuticals stipulates design of superior advanced materials for facile and cost effective separation of 90 Y. We demonstrate for the first time potential of birnessite type phylomanganates for radiochemical separation of clinical grade 90 Y from 90 Sr/ 90 Y mixture. Sodium birnessite was synthesized by controlled oxidation of MnCl 2 .4H 2 O in presence of excess of NaOH and characterized thoroughly for structure, microstructure and purity. Ion exchange experiments in the presence of 90 Sr/ 90 Y equilibrium mixture confirmed the exceptionally high selectivity of synthetic sodium birnessite for exchanging Sr 2+ ions and the conditions have been optimized to achieve radiochemically pure 90 Y (> 80% separation yield) meeting all the pharmaceutical requirements for its clinical use. Radionuclidic purity of 90 Y could be achieved to < 1 × 10 −4 % of 90 Sr which is well below the limit set internationally (2 × 10 −3 %). The separated 90 Y has been used to prepare 90 Y radiolabeled 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid coupled dimeric cyclic RGD peptide derivative [DOTA−E[c(RGDfK)] 2 ] and the biological efficacy of the radiotracer was established in C57/BL6 mice bearing melanoma tumors. The results indicated highly target specific radiotherapy suggesting the potential of sodium birnessite for cost effective radiochemical separation of 90 Y.