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Synthesis, Characterization, Photophysical and Electrochemical Studies of Ruthenium(II) Complexes with 4′‐Substituted Terpyridine Ligands and Their Biological Applications
Author(s) -
Ezhilarasu Tamilarasu,
Balasubramanian Sengottuvelan
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801624
Subject(s) - terpyridine , ruthenium , chemistry , stereochemistry , crystal structure , ligand (biochemistry) , electrochemistry , medicinal chemistry , crystallography , metal , organic chemistry , catalysis , biochemistry , receptor , electrode
Three 4′‐(4‐Methylbenzoate‐benzyloxy)‐2,2′:6′,2′′‐terpyridine (MBBtpy), 4′‐(4‐Ethylbenzoate‐benzyloxy)‐2,2′:6′,2′′‐terpyridine (EBBtpy) and 4′‐(5‐(1,3‐Dimethylbenzoate)‐benzyloxy)‐2,2′:6′,2′′‐terpyridine (DMBBtpy) ligands and seven ruthenium(II) symmetrical [Ru(MBBtpy) 2 ](PF 6 ) 2 (Ru1), [Ru(EBBtpy) 2 ](PF 6 ) 2 (Ru2), [Ru(DMBBtpy) 2 ](PF 6 ) 2 (Ru3) and unsymmetrical [Ru(MBBtpy)(EBBtpy)](PF 6 ) 2 (Ru4), [Ru(MBBtpy)(ttpy)](PF 6 ) 2 (Ru5), [Ru(MBBtpy)(Brttpy)](PF 6 ) 2 (Ru6), [Ru(MBBtpy)(HOttpy)](PF 6 ) 2 (Ru7) complexes were synthesized and characterized by UV/Vis, Fluorescence, FTIR, 1 H & 13 C NMR, ESI‐mass spectral studies and electrochemical studies. The crystal structure of HOttpy ligand was determined by single crystal X‐ray diffraction. The cyclic voltammograms of Ru(II) complexes exhibit a quasi‐reversible oxidation peak corresponding to Ru II /Ru III process. The peak current I pa and I pc increases with increase in scan rate. The Ru(II) complexes tested for in vitro antimicrobial activity against four human pathogens and fungus Candida albicans showed good antibacterial and antifungal activity. The binding of Ru(II) complexes with calf thymus DNA was determined by UV/Vis spectroscopy. The cleavage activity of ruthenium(II) complexes studied by gel electrophoresis indicates that these complexes can cleave pUC19 DNA more efficiently when compared to that of control.