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Carbon Dioxide as Building Block in the Synthesis of the Anti‐Infective Agent Hexamine
Author(s) -
Pereira Cláudia C. L.,
Gomes da Silva Marco D. R.,
Leal João P.,
Monteiro Bernardo
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801567
Subject(s) - hexamethylenetetramine , chemistry , formic acid , acetic acid , electrochemistry , yield (engineering) , inorganic chemistry , reducing agent , ionic liquid , copper , azide , nuclear chemistry , electrode , combinatorial chemistry , organic chemistry , catalysis , materials science , metallurgy
Electrochemical reduction of CO 2 in a EMIMBF 4 saturated solution in the presence of small amounts of the ionic liquid tetramethylguanidinium azide (TMGHN 3 ) yield as major product the nonvolatile hexamethylenetetramine (HMTA) also known as hexamine or methenamine. Vestigial concentrations of other reduction products like CO, formic acid and acetic acid were also detected and quantified. Both Cu and Cu/Zn electrodes were tested and presented a similar efficiency towards HMTA production. Electrode modification during CO 2 electro‐reduction, including copper nanoparticle (CuNPs) deposition, is the key feature that facilitates HMTA synthesis.