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A Molecular Hybridization Approach for Simple and Expeditious Synthesis of Novel Spiro[oxindoline‐3, 4′‐isoxazolo[5, 4‐ b ]pyrazolo[4, 3‐ e ]pyridines] in Water
Author(s) -
Kalita Subarna Jyoti,
Deka Dibakar Chandra
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801545
Subject(s) - catalysis , chemistry , reaction conditions , solvent , p toluenesulfonic acid , combinatorial chemistry , simple (philosophy) , organic chemistry , philosophy , epistemology
A simple, general and straightforward synthesis of novel spiro[oxindoline‐3, 4′‐isoxazolo[5, 4‐ b ]pyrazolo[4, 3‐ e ]pyridines] by one‐pot three‐component reaction of isatins, 5‐aminopyrazoles and 5‐aminoisoxazoles in water using p ‐toluenesulfonic acid monohydrate ( p ‐TSA.H 2 O) as the catalyst is described. The notable advantages of the protocol are good to excellent yields, short reaction time, simple purification process involving no chromatographic technique, use of water as the solvent system, application of p ‐TSA.H 2 O as cost‐effective catalyst, mild reaction conditions and operational simplicity that make the protocol highly attractive.