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Catalyst‐Free Selective Aza‐Michael Addition of 3‐Aminopyrazole to Nitroalkenes
Author(s) -
Li Zheng,
Song Wenli
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801526
Subject(s) - nitroalkene , catalysis , michael reaction , nitro , yield (engineering) , selectivity , chemistry , combinatorial chemistry , organic chemistry , materials science , enantioselective synthesis , alkyl , metallurgy
Catalyst‐free N 1 selective aza‐Michael addition of 3‐aminopyrazole to nitroalkenes is described. A series of 1‐(2‐nitro‐1‐arylethyl)‐1 H ‐pyrazol‐3‐amines were efficiently synthesized. The protocol has advantages of wide range of nitroalkene substrates, no catalyst, additives and bases, mild condition, high yield, and high selectivity. The method can also extend to gram scale.