Premium
A Visible‐Light‐Mediated Protocol: One‐Pot‐Three‐Component, Sustainable Synthesis of 1,3,4‐Thiadiazines
Author(s) -
Mishra Anu,
Rai Pratibha,
Singh Jaya,
Singh Jagdamba
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801508
Subject(s) - intramolecular force , yield (engineering) , visible spectrum , combinatorial chemistry , chemistry , component (thermodynamics) , reaction conditions , photochemistry , materials science , organic chemistry , catalysis , optoelectronics , metallurgy , thermodynamics , physics
An expeditious and proficient pH dependent, multicomponent strategy assisted by visible light for the synthesis of highly biologically significant scaffold “1,3,4‐thiadiazines” and its derivatives, has been reported here. The hallmark of the present protocol is the utilization of visible light at room temperature to form C−S and C−N bond via generation of some free radical intermediates followed by intramolecular cyclization without employing harsh reaction conditions. It also includes some other attributes like being environmentally benign and cost effective, involving short reaction time and possessing adaptability towards a wide range of substrates with good to excellent yield of product.