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A Selective Three‐Component, One‐Pot Approach for the Synthesis of 1,2‐Dihydroquinazolines and Quinazolines
Author(s) -
Dayakar Cherupally,
Raju BhimapakaChina
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801430
Subject(s) - cyclohexane , component (thermodynamics) , chemistry , ammonium , combinatorial chemistry , ammonium acetate , medicinal chemistry , organic chemistry , high performance liquid chromatography , physics , thermodynamics
A facile and selective method has been developed for the preparation of 1,2‐dihydroquinazolines 3 a‐u , quinazolines 5 a‐f and spiro cyclohexane‐1,2‐quinazolines 7 a‐d by the reaction of 2‐aminoacetophenones, benzophenones with β‐ketoesters, 1,3‐diketones and cyclic ketones in the presence of ammonium salts for the first time.