Premium
Biamphiphilic Ionic Liquids‐Drug Mixtures: Interactional and Morphological Aspects
Author(s) -
Vashishat Rajni,
Sanan Reshu,
Ray Debes,
Aswal Vinod Kumar,
Mahajan Rakesh Kumar
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801296
Subject(s) - dynamic light scattering , absorbance , ionic liquid , chemistry , gibbs free energy , spectroscopy , cyclic voltammetry , analytical chemistry (journal) , zeta potential , ionic bonding , absorption (acoustics) , materials science , organic chemistry , chromatography , thermodynamics , electrochemistry , nanotechnology , ion , physics , electrode , quantum mechanics , composite material , nanoparticle , catalysis
The interactional and morphology behavior of mixed system embracing chlorpromazine hydrochloride (CPZ) drug and surface active biamphiphilic ionic liquids (BAILs); 1‐hexyl‐3‐methylimidazolium dodecylsulfate ([C 6 mim][C 12 OSO 3 ]) and 1‐butyl‐3‐methylimidazolium octylsulfate ([C 4 mim][C 8 OSO 3 ]) at pH 7 have been investigated to develop new strategies to use BAILs as carriers of pharmaceutical active compounds. UV‐vis absorption spectroscopy and cyclic voltammetry (CV) methods are used to shed light on the foremost interactions governing CPZ + BAILs mixtures. The higher value of binding constant ( K a ) and Gibbs free energy change (Δ G ) for CPZ + [C 6 mim][C 12 OSO 3 ] mixture, determined from absorbance measurements depict the existence of more attractive interactions than CPZ + [C 4 mim][C 8 OSO 3 ]. The composition mediated self‐assembly of CPZ + BAIL mixed aggregates in bulk has been investigated by small angle neutron scattering (SANS), dynamic light scattering (DLS) and zeta potential measurements.