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Synthesis of Multinuclear Zn(II) Complexes Involving 8‐Aminoquinoline‐ Based Schiff‐Base Ligand: Structural Diversity, DNA Binding Studies and Theoretical Calculations.
Author(s) -
Ghorai Pravat,
Brandão Paula,
Bauzá Antonio,
Frontera Antonio,
Saha Amrita
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801273
Subject(s) - schiff base , chemistry , crystallography , density functional theory , ligand (biochemistry) , cubane , infrared spectroscopy , spectroscopy , dna , stereochemistry , crystal structure , computational chemistry , biochemistry , physics , receptor , organic chemistry , quantum mechanics
Abstract Four novel Zn(II) complexes [Zn 2 L 2 X 2 ] ( 1 ), [Zn 4 L 4 X(OH)(OH 2 )][ZnX 4 ] ⋅ H 2 O ⋅ CH 3 OH ( 2,3 ) and [Zn 4 L 4 X(OH)(OH 2 )](N(CN) 2 ) ( NO 3 ) ⋅ 2H 2 O ⋅ CH 3 OH ( 4 ) [where HL= ( E )‐2‐methoxy‐6‐((quinolin‐8‐ylimino)methyl)phenol and X= N 3 − , SCN − , SeCN − , N(CN) 2 − for 1–4 respectively] were synthesized and characterized by elemental analysis and different spectroscopic techniques viz. IR spectroscopy, UV‐vis spectroscopy and X‐ray crystallography. Complex 1 is hetero (μ‐azido and μ‐phenoxo) bridged dinuclear Zn(II) complex whereas complexes 2, 3 and 4 are tetranuclear Zn(II) complexes with corner‐defective cubane structure. Complexes 2–4 bare the rare examples of presence of three different binding modes (mono, di and triply ( μ 3 ) bridging) of phenoxo group of a Schiff base ligand in a single platform. All four complexes exhibit groove binding as well as weak electrostatic interaction with CT‐DNA (calf thymus‐DNA). DFT (density functional theory) and MEP (Molecular electrostatic potential) analysis are also studied for complexes 1–4 .