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An Improved Synthetic Protocol for Benzothiazoles via Ring Opening of Benzotriazole
Author(s) -
Kumar Dhananjay,
Singh Anoop S.,
Tiwari Vinod K.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801241
Subject(s) - benzotriazole , benzothiazole , reagent , chemistry , intramolecular force , ring (chemistry) , combinatorial chemistry , cleavage (geology) , silanes , organic chemistry , materials science , silane , fracture (geology) , composite material
An improved procedure for the construction of benzothiazole scaffold via intramolecular cyclative cleavage of benzotriazole ring under free radical condition was successfully accomplished. The protocol utilises NaBH 4 which regenerates the active reagent n ‐Bu 3 SnH in the reaction medium and makes this method cost effective and less toxic as a substitute of expensive and toxic silanes.