Premium
Influence of Functionalized η 6 ‐Arene Rings on Ruthenium(II) Curcuminoids Complexes
Author(s) -
Pettinari Riccardo,
Petrini Agnese,
Marchetti Fabio,
Di Nicola Corrado,
Scopelliti Rosario,
Riedel Tina,
Pittet Laure D.,
Galindo Agustín,
Dyson. Paul J.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801201
Subject(s) - ruthenium , chemistry , chelation , ligand (biochemistry) , stereochemistry , elemental analysis , curcumin , combinatorial chemistry , medicinal chemistry , organic chemistry , receptor , catalysis , biochemistry
A series of organometallic Ru(II) complexes containing functionalized η 6 ‐arene ligands, together with curcumin and bisdemethoxycurcumin as O,O’‐chelating ligands and their RAPTA (ruthenium arene complexes bearing the 1,3,5‐triaza‐7‐phosphaadamantane ligand) type ionic derivatives is reported. The complexes were characterized by elemental analysis, infrared, 1 H and 13 C NMR, ESI‐MS spectrometry, and by single‐crystal X‐ray structure analysis. The cytotoxic activity of the complexes has been evaluated against human ovarian A2780 and A2780cisR cancer cell lines as well as non‐tumorigenic human embryonic kidney HEK 293 cells.