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Guianofruits A and B from the Fruit Oil of Andiroba ( Carapa guianensis , Meliaceae) and Their Effects on LPS‐Activated NO Production
Author(s) -
Sasayama Atsumi,
Akita Keiko,
Oya Hiroto,
Kikuchi Takashi,
In Yasuko,
Fujitake Mihoyo,
Yamada Takeshi,
Tanaka Reiko
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801178
Subject(s) - meliaceae , chemistry , traditional medicine , stereochemistry , medicine
Two novel chukrasone‐type limonoids, Guianofruits A and B ( 1 and 2 ) were isolated from the fruit oil of Carapa guianensis A UBLET (Meliaceae), a traditional medicine in Brazil and Latin American countries. Their structures were elucidated based on spectroscopic analyses using 1D and 2D NMR techniques, HRFABMS, and X‐ray crystallography. Compounds 1 and 2 were rare chukrasone‐type limonoids that had once been isolated from Chukrasia tabularis . Compounds 1 and 2 were evaluated for their effects on the production of NO in LPS‐activated mouse peritoneal macrophages. The results of the NO inhibitory assay suggested that compound 1 is valuable as a potential inhibitor of macrophage activation.