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Polydopamine/Cellulose Nanofibrils Composite Film as Potential Vehicle for Drug Delivery
Author(s) -
Liu Yingying,
Wang Qingbo,
Shen Qianfeng,
Wu Meiyan,
Liu Chao,
Zhang Yuedong,
Yu Guang,
Li Bin,
Li Youming
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801118
Subject(s) - biocompatibility , composite number , drug delivery , cellulose , composite film , drug , biodegradation , materials science , chemical engineering , tetracycline hydrochloride , chemistry , nanotechnology , composite material , organic chemistry , tetracycline , pharmacology , antibiotics , medicine , engineering , biochemistry
Both cellulose nanofibrils (CNFs) and polydopamine (PDA) have attracted much attention due to their unique physical‐chemical properties and environmental benign nature. In this work, CNFs produced by 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) ‐mediated oxidation (named as TOCNFs) were combined with PDA to prepare a novel pH/near‐infrared‐responsive (NIR) PDA/TOCNFs composite film, which was used for drug delivery. Tetracycline hydrochloride (TH) was used as a model drug. Results indicated that the TH loaded in the PDA/TOCNFs composite films could be released in an on‐demand fashion under NIR exposure or at lower pH conditions, and the mechanism of drug release was mainly driven by Case‐II transport. The prepared PDA/TOCNFs composite film can be a promising new drug delivery vehicle for the sustained drug release applications, attributing to their long time period drug releasing property, sensitive pH/NIR responses, as well as their biodegradability and biocompatibility.