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Water‐PEG‐400 Mediated an Efficient One‐Pot Eco‐Friendly Synthesis of Functionalized Isoxazole Substituted Chromeno[2, 3‐ b ]pyridine‐3‐carboxylate Derivatives
Author(s) -
Ponduri Rajasekhar,
Kumar Pramod,
Vadali Lakshmana RAO,
Modugu Nagi Reddy
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801089
Subject(s) - isoxazole , peg ratio , polyethylene glycol , carboxylate , chemistry , substrate (aquarium) , pyridine , peg 400 , combinatorial chemistry , reaction conditions , environmentally friendly , organic chemistry , green chemistry , catalysis , reaction mechanism , ecology , oceanography , finance , economics , biology , geology
A green, straightforward, and efficient protocol for the synthesis of a new series of isoxazolyl chromeno[2, 3‐ b ]pyridine‐3‐carboxylate derivatives have been reported by one‐pot reaction of isoxazolyl enamino esters and 3‐formylchromones by employing water as a reaction medium and polyethylene glycol‐400 (PEG‐400) as the green promoter. The superiority of this protocol is environmentally benign, simple operation, metal‐free, broad substrate scope, good yields, less reaction time and PEG‐400 can be recovered and reused. Most significant of all, this protocol is green.