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Chirality‐Induced Variation in Interaction of Two Similar Copper(II) Coordination Polymers with Calf Thymus DNA: Exploration of Their Antimicrobial Activity and Cytotoxicity
Author(s) -
Khan Samim,
Masum Abdulla Al,
Giri Pritam,
Islam Md. Maidul,
Harms Klaus,
Chattopadhyay Shouvik
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801078
Subject(s) - circular dichroism , chirality (physics) , dna , chemistry , stereochemistry , cytotoxicity , docking (animal) , monomer , copper , binding site , schiff base , crystallography , in vitro , polymer , biochemistry , organic chemistry , medicine , nursing , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Two polynuclear end‐to‐end dicyanamide (dca) bridged copper(II) Schiff base complexes [Cu(L 1 )(μ 1,5 ‐dca)] n ( 1 ) and [Cu(L 2 )(μ 1,5 ‐dca)] n ( 2 ) {[HL 1 =(1‐(2‐(diethylamino)ethylimino)ethyl) naphthalene‐2‐ol] and [HL 2 =(1‐(2‐(dimethylamino)ethylimino)methyl) naphthalene‐2‐ol]} were synthesized and X‐ray characterized. Complex 1 crystallizes in chiral space group C 2 and complex 2 crystallizes in achiral space group P 2 1 /c. Interactions of both complexes with calf thymus DNA (CT DNA) were studied by UV‐vis and circular dichroism spectroscopy. Molecular docking studies were also carried out for both complexes to find their binding affinity using Alpha PMI as the placement methodology. Although docking studies indicated that the binding constants of both complexes with CT DNA were more or less same, UV‐Vis spectral data indicated that the binding constant of complex 1 with CT DNA is considerably large compared to that of complex 2 . As complex 1 is chiral and complex 2 is achiral, it may be concluded that the chirality of complex 1 played very significant role to binding of chiral DNA molecule. The antimicrobial activity were estimated by the determination of the minimal inhibitory concentration (MIC) using the broth microdilution method. The complexes showed high in vitro cytotoxicity against MDA‐MB 468 cells.