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Cobalt(I)‐Catalyzed Cycloaddition of Functionally Substituted Alkynes and 1,3‐Diynes to 1,3,5,7‐Cyclooctatetraene in the Synthesis of Bicyclo[4.2.2]deca‐2,4,7,9‐tetraenes
Author(s) -
D'yakonov Vladimir A.,
Kadikova Gulnara N.,
Gazizullina Guzel F.,
Dzhemilev Usein M.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801028
Subject(s) - cyclooctatetraene , cycloaddition , bicyclic molecule , chemistry , catalysis , cobalt , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , molecule
The [6π+2π]‐cycloaddition of O‐, S‐, N‐, Hal‐, and Si‐containing alkynes and 1,3‐diynes to 1,3,5,7‐cyclooctatetraene was accomplished for the first time using a Co(acac) 2 ‐based four‐component catalytic system [Co(acac) 2 /dppe/Zn/ZnI 2 ] to give previously undescribed functionally substituted bicyclo[4.2.2]deca‐2,4,7,9‐tetraenes in 72–95% yields. These products are of interest as key monomers for the synthesis of natural and synthetic biologically active compounds.