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Isocyanide‐Based Multi‐Component Reactions: One‐Pot Catalyst‐Free Synthesis of Carboxamides
Author(s) -
Mokhtari Tayebeh Sattaei,
Amrollahi Mohammad Ali,
Sheikhhosseini Enayatollah,
Sheibani Hasan
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201801001
Subject(s) - isocyanide , catalysis , chemistry , component (thermodynamics) , alkyl , methylene , combinatorial chemistry , organic chemistry , multi component reaction , reaction conditions , thermodynamics , physics
In this paper, a catalyst‐free procedure is described for the synthesis of novel carboxamide derivatives through a one pot five‐component reaction of cycloalkylidene‐substituted Meldrum's acid, alkyl isocyanide, and 4,4′‐methylene‐ or 4,4′‐oxydianiline. Any by‐product was not prepared through this reaction, and products were separated by a simple work‐up procedure. The other noticeable benefits of this procedure are good yields, mild reaction conditions and use of available materials.