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Sulfated‐Tungstate‐Catalyzed Synthesis of Ureas/Thioureas via Transamidation and Synthesis of Forchlorofenuron
Author(s) -
Wagh Ganesh D.,
Pathare Sagar P.,
Akamanchi Krishnacharya G.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800954
Subject(s) - tungstate , catalysis , sulfation , chemistry , substrate (aquarium) , combinatorial chemistry , solvent , urea , reaction conditions , organic chemistry , biochemistry , oceanography , geology
N, N’ ‐Disubstituted ureas and thioureas have been efficiently and expeditiously synthesized by transamidation reaction between unsubstituted or monosubstituted ureas/thioureas and amines under solvent‐free condition using sulfated tungstate as a heterogeneous mild solid acid catalyst. This protocol offers several advantages such as wide substrate scope, providing both symmetrical and unsymmetrical ureas and thioureas, solvent‐free reaction, recyclability of the catalyst and a simple work‐up procedure. Application of the methodology is demonstrated through simple and one step synthesis of forchlorofenuron [1‐(2‐chloropyridine‐4‐yl)‐3‐phenylurea] (CPPU), an approved plant growth regulator.