Synthesis and Characterization of Potential Impurities of Dolutegravir: A HIV Drug | Zendy

Gudisela Mura Reddy | Zendy; Bommu Praveen | Zendy; Navuluri Srinivasu | Zendy; Mulakayala Naveen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis and Characterization of Potential Impurities of Dolutegravir: A HIV Drug

Author(s) -

Gudisela Mura Reddy,

Bommu Praveen,

Navuluri Srinivasu,

Mulakayala Naveen

Publication year - 2018

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201800948

Subject(s) - dolutegravir , impurity , active ingredient , chemistry , high performance liquid chromatography , drug , human immunodeficiency virus (hiv) , ingredient , proton nmr , chromatography , combinatorial chemistry , nuclear chemistry , organic chemistry , pharmacology , antiretroviral therapy , medicine , virology , food science , viral load

Six major impurities were observed during the development of dolutegravir. All these impurities were identified by using HPLC and LC–MS analysis and were synthesized starting from (4R,12aS)‐7‐methoxy‐4‐methyl‐6,8‐dioxo‐3,4,6,8,12,12a‐hexahydro‐2H‐pyrido[1′, 2′:4,5] pyrazino [2, 1‐b][1, 3]oxazine‐9‐carboxylic acid 1 . All the synthesized impurities were characterized by using 1 H NMR, 13 C NMR, Mass and HPLC analysis. These compounds can be used as a reference standard for the active pharmaceutical ingredient manufactures and research organizations.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research