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Synthesis and Characterization of Potential Impurities of Dolutegravir: A HIV Drug
Author(s) -
Gudisela Mura Reddy,
Bommu Praveen,
Navuluri Srinivasu,
Mulakayala Naveen
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800948
Subject(s) - dolutegravir , impurity , active ingredient , chemistry , high performance liquid chromatography , drug , human immunodeficiency virus (hiv) , ingredient , proton nmr , chromatography , combinatorial chemistry , nuclear chemistry , organic chemistry , pharmacology , antiretroviral therapy , medicine , virology , food science , viral load
Six major impurities were observed during the development of dolutegravir. All these impurities were identified by using HPLC and LC–MS analysis and were synthesized starting from (4R,12aS)‐7‐methoxy‐4‐methyl‐6,8‐dioxo‐3,4,6,8,12,12a‐hexahydro‐2H‐pyrido[1′, 2′:4,5] pyrazino [2, 1‐b][1, 3]oxazine‐9‐carboxylic acid 1 . All the synthesized impurities were characterized by using 1 H NMR, 13 C NMR, Mass and HPLC analysis. These compounds can be used as a reference standard for the active pharmaceutical ingredient manufactures and research organizations.