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Aqueous Suzuki‐Miyaura Reaction with 0.6 Equiv. of Base: Green and Efficient Access to Biaryls and Unsymmetrical Terphenyls
Author(s) -
Li Xinmin,
Teng Yong,
Feng Fangfang,
Hu Qinghong,
Yuan Zeli
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800946
Subject(s) - base (topology) , chemistry , aqueous solution , palladium , catalysis , combinatorial chemistry , aqueous medium , ligand (biochemistry) , palladium catalyst , reaction conditions , block (permutation group theory) , organic chemistry , mathematics , biochemistry , receptor , mathematical analysis , geometry
Abstract A ligand‐free palladium‐catalyzed Suzuki–Miyaura reaction in water with 0.6 equiv. of base is described. This method enables the preparation of a variety of biaryls in high yields. Additionally, using bromo‐ N ‐methyliminodiacetic acid (MIDA) boronates as building block, one‐pot double Suzuki–Miyaura reaction has been achieved by controlling the amount of base, and various unsymmetrical terphenyls were prepared in moderate to good yields.