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Domino Oxidative Esterification of 2‐Oxo Alcohol Using 2‐Iodoxybenzoic Acid/I 2 : A Route to Synthesize α ‐Ketoester
Author(s) -
Sundaravelu Nallappan,
Chakraborty Ankush,
Sekar Govindasamy
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800941
Subject(s) - domino , yield (engineering) , alcohol , domino effect , substrate (aquarium) , chemistry , cascade reaction , combinatorial chemistry , oxidative phosphorylation , sequence (biology) , reaction conditions , protocol (science) , organic chemistry , catalysis , materials science , biochemistry , physics , oceanography , metallurgy , geology , medicine , alternative medicine , pathology , nuclear physics
An efficient metal‐free methodology for the synthesis of α‐ketoesters has been developed using α ‐hydroxy ketones and alcohols which follows domino alcohol oxidation and esterification reaction sequence. This methodology shows wide range of substrate scopes to bestow the products in excellent yield. A gram scale synthesis has been carried out to show the practical utility of the protocol.