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Synthesis, Characterization, Antibacterial and Antioxidant Studies of Some Heterocyclic Compounds from Triazole‐Linked Chalcone Derivatives
Author(s) -
Santosh Rangappa,
Selvam Mukunthan K.,
Kanekar Saptami U.,
Nagaraja Gundibasappa K.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800905
Subject(s) - chalcone , bacillus subtilis , chemistry , antibacterial activity , pyrazole , staphylococcus aureus , pseudomonas aeruginosa , triazole , nitro , pyrazoline , combinatorial chemistry , antioxidant , stereochemistry , bacteria , organic chemistry , biology , alkyl , genetics
In the current study, an efficient synthesis of new triazole‐linked chalcone 3 a‐g scaffold was performed by multistep reaction sequence and was screened for their antibacterial activity against Pseudomonas aeruginosa , Escherchia coli , Staphylococcus aureus and Bacillus subtilis . The preliminary result revealed that 3 f exhibited a promising antibacterial activity. Furthermore, 3 f was modified at α, β‐ unsaturated carbonyl segment to isoxazoline 4 a , pyrimidines 5 a , 6 a‐b , pyrazoles 7 a‐c and cyanopyridine 8 a . Within the modified compounds 7 b (4‐nitro‐substituted pyrazole) turn to be more potent against all bacterial strains. In addition compounds, 5 a and 8 a showed promising free radical scavenging activity.