Synthesis, Characterization, Antibacterial and Antioxidant Studies of Some Heterocyclic Compounds from Triazole‐Linked Chalcone Derivatives | Zendy

Santosh Rangappa | Zendy; Selvam Mukunthan K. | Zendy; Kanekar Saptami U. | Zendy; Nagaraja Gundibasappa K. | Zendy

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Synthesis, Characterization, Antibacterial and Antioxidant Studies of Some Heterocyclic Compounds from Triazole‐Linked Chalcone Derivatives

Author(s) -

Santosh Rangappa,

Selvam Mukunthan K.,

Kanekar Saptami U.,

Nagaraja Gundibasappa K.

Publication year - 2018

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201800905

Subject(s) - chalcone , bacillus subtilis , chemistry , antibacterial activity , pyrazole , staphylococcus aureus , pseudomonas aeruginosa , triazole , nitro , pyrazoline , combinatorial chemistry , antioxidant , stereochemistry , bacteria , organic chemistry , biology , alkyl , genetics

In the current study, an efficient synthesis of new triazole‐linked chalcone 3 a‐g scaffold was performed by multistep reaction sequence and was screened for their antibacterial activity against Pseudomonas aeruginosa , Escherchia coli , Staphylococcus aureus and Bacillus subtilis . The preliminary result revealed that 3 f exhibited a promising antibacterial activity. Furthermore, 3 f was modified at α, β‐ unsaturated carbonyl segment to isoxazoline 4 a , pyrimidines 5 a , 6 a‐b , pyrazoles 7 a‐c and cyanopyridine 8 a . Within the modified compounds 7 b (4‐nitro‐substituted pyrazole) turn to be more potent against all bacterial strains. In addition compounds, 5 a and 8 a showed promising free radical scavenging activity.

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