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Design, Synthesis and Anticancer Evaluation of Oxa/Thiadiazolylhydrazones of Barbituric and Thiobarbituric Acid: A Collective In Vitro and In Silico Approach
Author(s) -
Bhatt Priyanka,
Kumar Manoj,
Jha Anjali
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800832
Subject(s) - moiety , chemistry , thiobarbituric acid , in silico , in vitro , cell culture , stereochemistry , doxorubicin , cytotoxicity , combinatorial chemistry , barbituric acid , docking (animal) , bromide , biochemistry , organic chemistry , oxidative stress , biology , chemotherapy , medicine , genetics , nursing , lipid peroxidation , gene
A series of hybrid analogs of barbituric/thiobarbituric acid and 1,3,4‐oxa/thiadiazoles were synthesized by a sequence of diazotization and coupling reaction. Structures of all the synthesized compounds were confirmed by IR, NMR and mass spectroscopy. All the compounds were tested by in vitro 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) based assay against two human cancer cell lines: human breast adenocarcinoma cell line MCF‐7 and colorectal adenocarcinoma cell line HT‐29. Compound 11 which contained 1,3,4‐thiadiazole ring, p ‐NO 2 ‐phenyl group and thiobarbituric acid moiety displayed activity better than that of the standard drug Doxorubicin (DOX) used in the study. Target hunting and computational docking studies were used to explain the interactions between compound 11 and the potential targets.