Copper‐Catalyzed β‐Iodovinylation of Carbamates: Expedient Access to Highly Functionalized Vinyl‐Carbamates | Zendy

Ricard Simon | Zendy; Gag Alexandre | Zendy; Daoust Benoit | Zendy

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Copper‐Catalyzed β‐Iodovinylation of Carbamates: Expedient Access to Highly Functionalized Vinyl‐Carbamates

Author(s) -

Ricard Simon,

Gag Alexandre,

Daoust Benoit

Publication year - 2018

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201800824

Subject(s) - catalysis , alkene , surface modification , copper , chemistry , combinatorial chemistry , organic chemistry , polymer chemistry

A general and efficient method for the synthesis of β‐iodovinyl carbamates via copper‐catalyzed β‐iodovinylation of acyclic carbamates is described. This method uses readily available ( E )‐1,2‐vinyl diiodides and regioselectively affords the corresponding β‐iodovinyl carbamates in good yields with complete stereocontrol of the alkene. Further functionalization of these versatile products leads to a wide diversity of β‐functionalized vinyl‐carbamates in good to excellent yields.

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