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Copper‐Catalyzed β‐Iodovinylation of Carbamates: Expedient Access to Highly Functionalized Vinyl‐Carbamates
Author(s) -
Ricard Simon,
Gag Alexandre,
Daoust Benoit
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800824
Subject(s) - catalysis , alkene , surface modification , copper , chemistry , combinatorial chemistry , organic chemistry , polymer chemistry
A general and efficient method for the synthesis of β‐iodovinyl carbamates via copper‐catalyzed β‐iodovinylation of acyclic carbamates is described. This method uses readily available ( E )‐1,2‐vinyl diiodides and regioselectively affords the corresponding β‐iodovinyl carbamates in good yields with complete stereocontrol of the alkene. Further functionalization of these versatile products leads to a wide diversity of β‐functionalized vinyl‐carbamates in good to excellent yields.