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CuO Nanoparticles as An Efficient Heterogeneous Catalyst for the 1,3‐Dipolar Cycloaddition of Dicarbonyl Compounds to Azides
Author(s) -
da S. Dias Cássio,
de M. Lima Thiago,
Lima Carolina G. S.,
ZuekrmanSchpector Julio,
Schwab Ricardo S.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800816
Subject(s) - cycloaddition , catalysis , yield (engineering) , chemistry , combinatorial chemistry , oxide , methylene , nanoparticle , 1,3 dipolar cycloaddition , aryl , molecule , heterogeneous catalysis , organic chemistry , nanotechnology , materials science , alkyl , metallurgy
Substituted 1,2,3‐triazoles are important heterocyclic molecules with applications in diverse research areas. The organocatalytic (3+2) cycloaddition reaction of azides with active methylene compounds has proven to be a powerful strategy for the synthesis of a variety of 1,2,3‐triazoles with different substituents. However the reported methods in the literature, commonly used a homogenous organocatalyst. Considering this point, here we have reported a novel heterogeneous protocol for the synthesis of 1,4,5‐trisubstituted 1,2,3‐triazoles by reaction of different dicarbonyl compounds with aryl azides catalyzed by copper oxide nanoparticles under microwave irradiation. The important features of this methodology are high yield products, short reaction times and recyclability of the CuO catalyst.