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A Domino Reaction of Pyridinium Salts: Efficient Synthesis of 4,5‐Disubstituted 1,2,3‐( NH )‐Triazoles
Author(s) -
Wu GuangLong,
Wu QinPei
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800669
Subject(s) - pyridinium , chemistry , sodium azide , domino , azide , salt (chemistry) , ring (chemistry) , medicinal chemistry , pyridinium compounds , triazole , organic chemistry , combinatorial chemistry , catalysis
A one‐pot mild and metal‐free procedure for efficient synthesis of 4,5‐disubstituted 1,2,3‐( NH )‐triazoles has been developed through the sequentially reaction of pyridinium salts with aldehydes and sodium azide. In the presence of L‐proline, a key intermediate, an olefinic pyridinium‐salt, is in situ generated via coupling of pyridinium salts with aldehydes and cyclizes with azide ion to form a triazole ring.