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Metal‐Free Selective C2‐H Amidation of 8‐Amidoquinolines by Using Isocyanide as the Source of Amide
Author(s) -
Hao Wenyan,
Wang Yuyun,
Miao Jiankang,
Liu Yunyun
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800647
Subject(s) - isocyanide , amide , chemistry , quinoline , combinatorial chemistry , transition metal , metal , organic chemistry , catalysis
Abstract An unanticipated and highly efficient selective amidation in the C2 position of 8‐amidoquinolines has been developed via C‐H bond elaboration. The method is transition‐metal‐free, operationally simple with broad functional group tolerance. In this work, isocyanide has been successfully utilized as the source of amide. Furthermore, various kinds of 8‐amidoquinolines in combination with different substituted isocyanides under oxidative condition resulted in direct access to N ‐quinoline‐2‐carboxamides in good yields.