Premium
Scope and Limitations of Leuckart‐Wallach‐Type Reductive Amination: Chemoselective Synthesis of Tertiary Amines from Aldehydes under Neat Conditions
Author(s) -
De Aramita,
Ghosal Nirnita Chakraborty,
Mahato Sachinta,
Santra Sougata,
Zyryanov Grigory V.,
Majee Adinath
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800636
Subject(s) - reductive amination , chemistry , formic acid , organic chemistry , primary (astronomy) , tertiary amine , environmentally friendly , amination , solvent , combinatorial chemistry , scope (computer science) , computer science , catalysis , ecology , physics , astronomy , biology , programming language
We have developed a convenient method to synthesize tertiary amines selectively with a variety of aldehydes and primary amines using commercially available formic acid as reducing agent. In our methodology we have shown that we can prepare a variety of tertiary amines by changing both the amines as well as aldehydes. Clean reaction, operational simplicity, easily accessible reactants, metal and solvent‐free and environmentally friendly reaction conditions are the notable advantages of this procedure.