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Cobalt‐Copper Catalyzed C(sp2) – N Cross Coupling of Amides or Nitrogenated Heterocycles with Styrenyl or Aryl Halides
Author(s) -
Ghosh Tubai,
Maity Pintu,
Ranu Brindaban C.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800575
Subject(s) - halide , aryl , chemistry , iodide , catalysis , pyrazole , copper , medicinal chemistry , cobalt , stereoselectivity , combinatorial chemistry , organic chemistry , alkyl
An efficient C(sp2) – N cross coupling of cyclic and acyclic amides with styrenyl/aryl/heteroaryl halides catalyzed by cobalt acetylacetonate in combination with copper(I) iodide, has been achieved. A library of diversely substituted cyclic and acyclic enamides have been obtained in high yields by this procedure. The reaction is stereoselective producing ( E )–enamides from trans ‐styrenyl halides and ( Z )‐ products from cis ‐halides. This procedure has been successfully employed for the coupling of other N‐heterocycles such as pyrazole, imidazole and triazole with aryl/styrenyl/heteroaryl halides to produce the corresponding N‐coupled products. A probable mechanism has been suggested.