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Metal‐Free Debromination of 5‐Bromopyrimidine Derivatives Using DMF/Trialkylamine as the Hydrogen Source
Author(s) -
Mousavi Mahsa,
Bakavoli Mehdi,
Shiri Ali,
Tajabadi Javad
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800516
Subject(s) - chemistry , metal , catalysis , hydrogen , organic chemistry , medicinal chemistry
Attempted heterocyclization of 5‐bromo‐2,4‐diamino‐6‐substituted pyrimidines in a mixture of DMF and trialkylamines (Et 3 N or N,N ‐diisopropylethylamine) under mild conditions, led to the formation of new dehalogenated derivatives as the main product. This metal‐free catalyzed debromination process presents DMF/R 3 N combination as a potential metal‐free reductive system.