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Tumor Microenvironment Responsive Oxygen‐Self‐Generating Nanoplatform for Dual‐Imaging Guided Photodynamic and Photothermal Therapy
Author(s) -
Yin Zhihui,
Chen Dapeng,
Zou Jianhua,
Shao Jinjun,
Tang Hao,
Xu Hong,
Si Weili,
Dong Xiaochen
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800498
Subject(s) - photothermal therapy , photodynamic therapy , singlet oxygen , tumor microenvironment , photosensitizer , in vivo , materials science , nanotechnology , chemistry , cancer research , oxygen , photochemistry , medicine , tumor cells , microbiology and biotechnology , organic chemistry , biology
Developing a smart nanoplatform for cancer diagnosis and treatment under the hypoxic and acidic tumor microenvironment (TME) remains a great challenge. Herein, a TME responsive Ce6‐MnO 2 /CNTs (CMCs) nanoplatform with oxygen‐self‐generation property and enhanced permeability and retention effect (EPR) has been successfully prepared for synergistic photothermal/photodynamic therapy. Carbon nanotubes (CNTs) were uniformly coated with cross‐linked MnO 2 flakes, then the obtained MnO 2 /CNTs (MCs) were incubated with Chlorin e6 (Ce6) to fabricate CMCs. In the TME, MnO 2 in CMCs (targeted accumulation in tumor site) could react with endogenous H 2 O 2 and H + to supply oxygen in situ for Ce6 to produce cytotoxic singlet oxygen ( 1 O 2 ), which significantly enhances the photodynamic therapy (PDT) efficiency. Moreover, CNTs could also be utilized as a photothermal agent for both photothermal imaging and therapy (PTT) to further improve the therapeutic efficacy. In addition, the photosensitizer Ce6 could also be used for in vitro and vivo fluorescence imaging. The results demonstrate that the smart tumor microenvironment responsive nanoplatform Ce6‐MnO 2 /CNTs with EPR effect and oxygen‐self‐generation property hold great potential in photothermal/fluorescence imaging guided synergistic PDT/PTT for cancer treatment in clinic.