Premium
Polyethylene Glycol‐Bonded Tetraethyl Ammonium Hydroxide ([PEG‐TEA]OH): A New Surfactant‐Combined Base Catalyst for the Synthesis of 2,3‐Dihydroquinazolin‐4(1 H )‐ones in Water
Author(s) -
Safaei Hamid Reza,
Shekouhy Mohsen,
Ghorbanzadeh Somayeh
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800456
Subject(s) - polyethylene glycol , ammonium hydroxide , catalysis , pulmonary surfactant , chemistry , peg ratio , base (topology) , tetraethyl orthosilicate , hydroxide , organic chemistry , ammonium , peg 400 , condensation , polymer chemistry , nuclear chemistry , mathematical analysis , biochemistry , physics , mathematics , finance , economics , thermodynamics
The polyethylene glycol‐bonded tetraethyl ammonium hydroxide [PEG‐TEA]OH was synthesized and characterized as a new reusable biodegradable surfactant‐combined base catalyst. The obtained catalyst was successfully applied for the synthesis of 2‐substituted‐2,3‐dihydroquinazolin‐4(1 H )‐ones in water via a newly reported synthetic reaction that is the condensation of 2‐aminobenzonitrile and carbonyl compounds. Using this method, a broad range of carbonyl compounds (aromatic as well as aliphatic aldehydes and ketones) were successfully reacted with 2‐aminobnzonitrile in water as a benign and completely nontoxic reaction medium and corresponding products were obtained in good to excellent yields in very short period of time.